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In our study ( we observed that while weight loss remains an important driver of response in MASH, there are also signals consistent with weight-lossindependent pathway modulation, of inflammatory and fibrotic biological processes

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To those who are still bleating that we should keep trying diet and exercise before resorting to use of anti obesity medications or that we can maintain long term weight loss effected by use of medication by ceasing medication and relying on diet and exercise alone- please look up all the research which shows that lifestyle intervention alone can only effect 5-7% weight loss and this weight will also be regained in the next year or two