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Yes, prices are expected to drop due to increased competition, generic versions, potential price negotiation in Medicare, and other factors

As with other GLP-1 medicines, people with: A history of severe gastrointestinal disease Pancreatitis Significant kidney or liver issues should only use GLP-1 treatments under close clinical monitoring

The FDA has approved these agents for type 2 diabetes management (not type 1 diabetes or diabetic ketoacidosis), with select formulations also approved for chronic weight management in adults with obesity or overweight with weight-related comorbidities

169 First-generation agents, including verapamil and cyclosporin A, showed in vitro efficacy but were hampered by off-target toxicity and limited clinical applicability