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This finding is not surprising considering the baseline characteristics of the enrolled patients, which initially had pathological but highly variable average values of visceral adipose tissue, with minimum values as low as 0.6 liters, within normal range
This is because injectable drugs do not encounter barriers like the gastrointestinal tract and are rapidly absorbed into the bloodstream
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If phenobarbital is utilized in a patient with hepatic dysfunction, it should be dose-reduced
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