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The main additional risk when combining with glipizide is low blood sugar

GLP-1 agonists showed cardiovascular benefits, reducing heart attack and stroke risk in people with Type 2 diabetes

10.1161/CIRCULATIONAHA.118.033898 217

Preclinical Models and Behavioral Paradigms Preclinical studies used validated behavioral paradigms to evaluate substance-seeking behavior, including oral self-administration, intravenous administration, drug- and cue-induced reinstatement, conditioned place preference, and operant conditioning