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Hyperglycemia induces NF-kappaB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin
Despite the promise of these new therapies to address all parts of the CVD/diabetes/obesity triad, approval and broad reimbursement for all these uses are likely still a few years off
Risk differences were higher in men, patients aged 50 years or older, and those with cardiovascular disease or ophthalmic conditions, with minimal differences in women and those younger than 50 years
In this context, the concept of biased agonism 37 has emerged, in which ligands can selectively engage in different intracellular pathways, potentially allowing specific cellular responses
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