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Preclinical studies in animal models such as SpragueDawley rats, C57BL/6 mice, and Wistar rats have reported encouraging outcomes [93]

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Additionally, a positive correlation has been observed between serum iron levels and transferrin saturation and the progression of OA (156)

Hormonal imbalances can trigger weight gain or resistance to weight loss, while excess weight can disrupt hormone levels, potentially leading to hormone imbalance and metabolic disorders