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A study with patients with HSE simultaneously compared HSV-1 isolates from the mouth and brain of infected individuals and showed that five out of eight isolate pairs were identical, as determined by restriction endonuclease analyses indicating that HSV-1 infection in a latent state in the TG acquired in a previous orolabial infection may reactivate from this site and reach neurons in the CNS (Whitley et al., 1982)

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Also, Cox proportional hazards regression models were fit to evaluate continuous metabolite measurements, as well as to adjust for outcome-related covariates

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