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Contact your supervising clinician promptly if you experience: Persistent or severe vomiting that prevents adequate fluid intake Signs of dehydration (dark urine, dizziness, confusion) Severe abdominal pain, particularly radiating to the back (which may indicate pancreatitis) Upper right abdominal pain, fever, or jaundice (which may indicate a gallbladder problem) The glucagon receptor activity of retatrutide means that blood glucose monitoring is particularly important for individuals with diabetes who are also taking insulin or sulphonylureas, as these combinations may increase the risk of hypoglycaemia (low blood sugar)