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Inhibition of Glutamate cysteine ligase depletes neuronal glutathione, elevates glutamate and increases excitatory neurotransmission Glutamate cysteine ligase (GCL) is the rate limiting step for glutathione synthesis, and utilizes glutamate as a substrate
They are grouped together by function and popular usage, not by chemical family
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After this "reset," restarting the peptide often produces a second wave of effectiveness often better than the first
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