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This is deeply connected to citrate availability, since citrate is a cataplerotic compound in TCA cycle, which derives from oxaloacetate and acetyl-CoA, but it can also be deviated to feed other metabolic pathways [60, 61]
Namely, it is always applied alone (Sikiric et al., 1993
These short half-life values emphasize curcumins rapid metabolism and elimination, contributing to its limited systemic bioavailability and therapeutic efficacy after oral intake (117)
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