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Compared to other medications, semaglutide has been found to be more effective for weight loss than liraglutide ( Saxenda ), though not as effective as tirzepatide (Zepbound)
For the first time in the history of obesity medications we see weight loss efficacy of a magnitude that might raise concern about excessive loss of lean body tissue due to the initial pronounced reduction in energy intake and subsequent risk of protein deficiency
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Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels
