difference between glp-1 and glp-1/gip Dose-equivalence reference based on pivotal GLP-1/dual-agonist trials: SURMOUNT-1 (tirzepatide/Zepbound, 72 weeks) STEP-1 (subcutaneous semaglutide/Wegovy, 68 weeks) OASIS-4 (oral semaglutide/Wegovy, 64 weeks). For educational comparison only—these are 🔗 https://bit.ly/4p18nLz Curious how GLP-1

Research using MC4R knockout mice and selective MC4R antagonists has established MC4R as the primary receptor mediating MT-IIs pro-erectile and pro-sexual effects with MC4R-null mice showing substantially reduced or absent MT-II-induced erections and sexual behaviour, and MC4R-selective antagonists blocking these responses at doses not affecting MT-IIs melanogenic activity

Brand-name GLP-1 drugs such as Ozempic, Wegovy and Mounjaro are manufactured by Novo Nordisk and Eli Lilly and Company, and approved by the U.S

note that daily dosing is only for the activation phase of the GLOW protocol (weeks 1-4) , decreasing to 5x per week for the remodeling phase (weeks 5-8), and further reduced to 2-3x per week during maintenance (weeks 9-12)

(4) Berlan M, Galitzky J, Riviere D, Foureau M, Tran MA, Flores R, Louvet JP, Houin G, Lafontan M