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Tirzepatide vs Retatrutide: The Big Differences at a Glance A big difference between these two meds is that tirzepatide is currently available (under the brand names Mounjaro and Zepbound) while retatrutide is still considered an investigational drug, undergoing clinical trials

Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist with no MHRA or EMA marketing authorisation as of 2024