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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate
Expert Opin Ther Pat
Dietary counseling should focus on high-protein intake (6080 g daily), adequate hydration, vitamin and mineral supplementation adherence, and avoidance of high-calorie liquids and grazing behaviors
If the medication freezes, the proteins can break down, making the drug ineffective
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