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Dankers AC, Mutsaers HA, Dijkman HB, van den Heuvel LP, Hoenderop JG, Sweep FC, et al

The reversible reduction of GSSR substrates usually requires only the first active-site cysteinyl residue and is therefore catalyzed by a monothiol mechanism with ping-pong bi-bi kinetic patterns (Fig

The STEP 1 trial showed participants lost an average of 14.9% of their body weight over 68 weeks at the 2.4mg dose