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Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis
This leads to uncontrolled cell proliferation, aberrant angiogenesis, and suppression of apoptosis, ultimately promoting tumorigenesis ( KRAS promotes ferroptosis resistance primarily through two interconnected mechanisms
Understanding these factors helps clinicians and patients make informed decisions about medication use and implement appropriate monitoring strategies
NAD+ therapies typically include precursors like NMN or NR (nicotinamide riboside) or direct boosters like sirtuins activators
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