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It is essential that folate deficiency is diagnosed as soon as possible, so that it can be treated
In those circuits, GLP-1 receptor activation reduces the rewarding value of palatable food and modulates dopaminergic tone in ways consistent with behavioral restraint rather than hedonic amplification [16,17]
The severity was described as "mostly mild to moderate" in the NEJM publication, with events partially mitigated by the lower starting dose protocol (Jastreboff et al., NEJM 2023)
However, head-to-head trials and meta-analyses reveal distinct profiles
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