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The reason lies in the fact that the clinical trials used obese patients (high body mass index = more fat to reduce), whereas Mounjaro was tested on people with Type 2 diabetes (body mass index may be lower)
R., Trakht, I., Srinivasan, V., Spence, D
For example, metalloproteinase inhibitor 4 (TIMP4) was upregulated by semaglutide in STEP 2 but not STEP 1
Some studies show it can improve blood sugar control and reduce weight gain in ways that overlap with GLP-1 pathways
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