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If that pathway isn't activating, the problem is upstream

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10.3390/antiox9080647 116 QinK.HanC.ZhangH.LiT.LiN.CaoX

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These pathways not only preserve proteome integrity but also offer powerful therapeutic opportunities, as demonstrated by the emergence of proteasome inhibitors, autophagy modulators, and molecular chaperone-targeting agents in clinical medicine (Tables 1 and 2)

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