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B12 is naturally found in animal products, such as meat, poultry, fish, dairy, and eggs
Clinical trials show average weight loss of 15-22% over 68 weeks with GLP-1 receptor agonists, though individual results vary based on genetics, lifestyle, and adherence
GLP-1 analogues, once viewed mainly as glucose-lowering drugs, are now redefining obesity treatment, cardiovascular risk management, chronic kidney disease care, MASH/NASH research, and long-term metabolic disease prevention
Nonetheless, due to biological and physiological differences between a small animal model and humans, such as a thinner cartilage, possible spontaneous healing of defects, biomechanics, and physical loading in small animals, thus, an additional chondral defect repair study using minipigs should be conducted to confirm these effects
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