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Materials and methods Mouse models A tamoxifen-inducible myofibroblast-specific IGF-1R KO (CFIGF1RKO: IGF-1R fl/fl Postn MCM ) mouse model was generated by crossing mice homozygous for floxed IGF-1R alleles in which loxP sites flank exon 3 of the IGF-1R gene [6] with mice containing a tamoxifen-inducible Cre recombinase (MerCreMer) expression cassette within the Postn genetic locus (PostnMCM) [36]
Lei C, Davoodi P, Zhan W, Chow PK-H, Wang C-H
Jason Zhang, a gastroenterologist with Boston Childrens Hospital
Less commonly used glucose-lowering medications Alpha-glucosidase inhibitors improve glycaemic control by reducing postprandial glycaemic excursions and glycaemic variability and may provide specific benefits in cultures and settings with high carbohydrate consumption or reactive hypoglycaemia [221, 222]
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