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One of the active forms of cobalamin, methylcobalamin, serves as a cofactor for methionine synthase, facilitating the conversion of homocysteine to methionine (7, 20, 25, 72, 73)

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Introduction Doxorubicin (DOX) is an anthracycline antibiotic derived from Streptomyces peucetius and serves as a cornerstone in the treatment of various malignancies, including breast cancer, leukemias, lymphomas, and sarcomas ( The mechanisms underlying DOX-induced cardiotoxicity (DOX-IC) are multifactorial, involving excessive ROS production, mitochondrial dysfunction, iron overload, and the activation of apoptotic and inflammatory pathways ( Natural compounds with strong antioxidant and anti-inflammatory properties represent a promising therapeutic approach