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For both therapeutic classes, this increased risk of gallbladder or biliary diseases has been thought to be driven by the inhibition of the secretion of cholecystokinin by GLP-1, leading to impaired gallbladder motility and contractility [64, 65]
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Severe Digestive Complications Despite being newer, tirzepatide drugs are already associated with: Gastroparesis (stomach paralysis) Ileus (intestinal blockage) Severe persistent vomiting Gastric outlet obstruction Cyclic vomiting syndrome The mechanism is similar to semaglutide: excessive slowing of gastric emptying
Presented for research literature review only Begum F et al
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