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To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig
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While these products may be easy to find online, that convenience often comes at the expense of safety, she explains
However, most of the glutamate orally ingested is known to be metabolized in the small intestine and not to enter the circulation (Windmueller and Spaeth 1975)
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