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Park et al., 2016) and neurodegenerative diseases (Pickart et al., 2012, 2017)

Doses in research trials have ranged up to 2 mg per kg of body weight per day (max ~50 mg/day) to achieve therapeutic effects [5]

Aug 2021;263:72-78

A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction