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Clinical and preclinical studies have revealed that AKI is a complex systemic disease with effects on virtually every organ 2 , including the lung 3,4 , heart 5,6 , liver 7,8 , brain 9 , and intestine 10
Functional studies further implicate occludin in maintaining epithelial architecture
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Here are two notable trials underlying these potential benefits: In a study involving 107 patients with alcohol (n = 47) or opiate (n = 60) withdrawal symptoms, DSIP was administered intravenously based on the hypothesis of its agonistic activity on opiate receptors
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