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Shatsky[23], who examined evidence derived from the use of oral and intramuscular administration, indicated that high dose oral administration appeared to be safe, effective and cost-effective, although long term clinical trials were required to confirm this
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The meta-analysis findings regarding obesity and heart health could portend further changes to treatment guidelines, or perhaps even lead to regulatory bodies recommending GLP-1s as a means of managing both obesity and heart health
Obesity drug coverage in Medicaid remains limited, with 13 state Medicaid programs covering GLP-1s for obesity treatment under FFS as of January 2026 (Figure 1)
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