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Tier 3: 10-15% Weight Loss (Early Data / Oral Agents)# This tier consists primarily of oral formulations with shorter trial durations or lower doses: VK2735 SC (14.7% at 13 wk) -- Impressive trajectory for a 13-week trial Oral semaglutide 25 mg (13.6% at 64 wk) -- Approved dose, competitive with injectable Oral amycretin (13.1% at 12 wk) -- Extraordinary 12-week result for an oral drug Oral VK2735 (12.2% at 13 wk) -- Strong oral dual agonist result Oral ribupatide (~12% at 26 wk) -- Dual agonist oral formulation Orforglipron (11.2% at 72 wk) -- The most mature Phase 3 oral data Rankings by Mechanism# GLP-1 Monoagonists# GLP-1/GIP Dual Agonists# GLP-1/Glucagon Dual Agonists# GLP-1/Amylin Combinations# Triple Agonists# Antibody Conjugates# Weight Loss Per Week Comparison# Since trial durations vary widely, examining the rate of weight loss provides additional context: Note: This metric favors shorter trials because weight loss rate typically declines over time as patients approach a new steady state

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Patients appreciate being able to browse provider profiles, read reviews, and select a clinician who matches their preferences rather than being assigned one Same-day appointments available in many cases The breadth of medication options, 14 different weight loss prescriptions, is cited as allowing providers to tailor treatment to individual patient profiles rather than defaulting everyone to the same protocol Costco partnership praised by members for adding a familiar, trusted access point to what is otherwise a purely digital experience Common complaints: The 28-day billing cycle causes surprise charges for patients expecting monthly billing aligned to calendar months Some patients report customer service issues, including slow response times and difficulties with cancellations No intensive coaching lifestyle support is limited compared to platforms with dedicated coaches or dietitians Provider variability because Sesame is a marketplace with independent providers setting their own rates and approaches, patient experience can vary significantly depending on which provider is selected Compounding Pharmacies Used Sesame Care prescribes both FDA-approved brand-name medications and compounded semaglutide, depending on clinical appropriateness and patient need