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Specifically, glucagon-like peptide-1 receptor agonists (GLP-1RAs
This epigenetic modification activates GCLC transcription, enhances glutathione synthesis, and protects against lipid peroxidation and ferroptosis, thereby driving chemoresistance in colorectal CSCs
Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)
3.2 Express Scripts / Evernorth (Cigna) Express Scripts (PBM arm of Cigna/Evernorth) similarly manages a large share of commercial and Medicare Part D beneficiaries
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