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Combination with insulin or sulfonylureas , due to risk of hypoglycaemia (though the GLP-1 RA itself rarely causes hypoglycaemia).

Su2057: a genetic risk score associated with nausea resulting from GLP-1 receptor agonist treatment: a post-hoc analysis of a randomized controlled trial of liraglutide

In clinical research, dose escalation and monitoring rules are set by a study protocol

The 2.4 mg group lost the most weight, which means that among adults suffering from overweight or obesity and T2DM, SMG 2.4 mg once a week has achieved significant clinically significant weight loss ( 2 (or 27 kg/m 2 with more than 1 body weight-related coexisting disease)