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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

When and How to Take BPC-157 Best Timing : Many users prefer to take their daily dose in the morning with water, ideally on an empty stomach or with a light meal for better absorption

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In contrast, acetaminophen lacks this reinforcing effect, making it a safer option for long-term pain management without the risk of physical dependence or withdrawal