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The LEGEND-T2DM initiative conducted an even larger retrospective analysis across multiple international databases
At the fasting state, NAFLD subjects had higher levels of chemokines CCL16, CCL21 and CCL23, hepcidin, complement decay accelerating factor (DAF), C1 esterase inhibitor, TNF receptor superfamily member 1B, and IL-1 receptor-like 1
Signals to decrease your maintenance dose: You are still losing weight unintentionally after 8 weeks at goal You experience persistent nausea, constipation, or diarrhea that interferes with daily life Your BMI drops below the healthy range (under 18.5) You have maintained goal weight for 6 or more months and want to test a lower dose Signals to increase your maintenance dose: Weight has increased by 5 or more pounds over 4 consecutive weeks Appetite and cravings have returned to pre-treatment levels You have experienced a major life stressor (job change, illness, injury) that disrupts diet and exercise routines Seasonal weight gain exceeds your historical pattern by 3 or more pounds How to adjust: Move in 2.5 mg increments
He encourages clinicians to take the time to educate patients and says the studies also included low dose regimens, so starting with low doses and using very gradual increases may facilitate better long-term continuation and benefits
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