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Altering the pharmacokinetic profile, even while maintaining the same total weekly dose, could theoretically affect receptor desensitization patterns, immune response to the peptide, or metabolic adaptation in ways that have not been characterized
Tsibadze, N
Type 2 Diabetes# Recommendation : Tirzepatide Reason : Five SURPASS trials with 9,000+ patients, FDA approval, and demonstrated superiority over semaglutide
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