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Activation of Tissue Remodeling Proteases GHK-Cu activates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in a balanced way that facilitates controlled extracellular matrix remodeling breaking down damaged collagen and replacing it with new, organized fibrillar collagen rather than scar tissue
0.025-0.05% prescription tretinoin and 0.5-1% OTC retinol produce broadly comparable photoaging outcomes in head-to-head trials, though tretinoin acts faster
2014;9(4):e95008
None of these peptides are FDA-approved for the uses described here
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