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Discontinuation rates due to adverse events remain low across studies (approximately 4-10%), indicating good overall tolerability
Ca 2+ signaling and/or ROS have been shown to contribute to eryptosis induced by cetyltrimethylammonium bromide-coated Au nanorods [454], self-assembling antimicrobial nanofibers [457], Fe 3 O 4 NPs [456], TiO 2 NPs [455], SOD-CAT-poly(lactic-co-glycolic acid) NPs [460], and dextran-polyacrylamide-embedded Ag NPs [461]
44 The release of zinc from the ER is likely mediated by ZIP7, as ZIP7 predominantly resides in the ER, and silencing ZIP using siRNA prevented the occurrence of the zinc wave
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