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They had every reason not to go out there and cheer me on. Why Jelly Roll Avoided Using GLP-1 Medications for Weight Loss In his January 2026 cover story for Mens Health , Jelly Roll revealed why he chose not to use GLP-1 medications, including Ozempic, Mounjaro and Wegovy, to help achieve his weight loss goals
Research Insights Weight Loss and Obesity Management Clinical studies show that individuals treated with GLP-1 (S) experienced weight reductions of up to 15% over 68 weeks, significantly outperforming placebo groups ( 2, 3 )
It connects the absorption of nutrients starting with the gastrointestinal tract using hormone secretion from the pancreas
Moreover, small-molecule GLP-1RAs offer a solution to the bioavailability limitations faced by oral peptide-based agents, which often depend on absorption enhancers (e.g., SNAC) and strict fasting protocols [74]
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