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-KG is generated for the TCA cycle and is used for oxidative phosphorylation (OXPHOS) 21
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
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Tirzepatide , on the other hand, is a twincretin , activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors
