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Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]

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However, larger and long-term studies are warranted to generate more evidence

It effectively prevents high-altitude headache and AMS, but does not facilitate acclimatization and is less effective than acetazolamide