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Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
The registered phase 1 oral trial (NCT02637284, 42 subjects, 2015-2016) has never posted results
For men looking into ways to potentially support muscle growth, recovery, or even just combat some of the effects of aging, Ipamorelin might be something to consider
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