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The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver (hepatocytes) and kidney (proximal tubules)

For instance, future research may focus on exploring structureactivity relationships of NRF2 activators to identify more effective and selective compounds, while investigating their potential therapeutic applications across diverse disease models

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Our model results correspond well with measurements of plasma GSH after doses of various sizes (Figure6)