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Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells
In the first, it undergoes oxidation within the TCA cycle [often called the Szent-GyrgyiKrebs cycle, acknowledging the Nobel Prize (1937) winning contributions of Albert Szent-Gyrgyi in identifying the fumarate, malate and oxaloacetate forming reactions towards the end of the cycle, and those of Hans Adolf Krebs, Nobel Prize (1953), for elucidating the details of the overall cycle], ultimately being converted to pyruvate and lactate in the cytosol through a metabolic process known as glutaminolysis (represented by blue arrows) (Albert Szent-Gyrgyi FactsNobelPrize.org n.d
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It is a single small aromatic molecule designed to be membrane-permeable, so in principle it can survive the gut and cross into cells
