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KEGG pathway and Gene Ontology (GO) enrichment analyses identified the PI3K-AKT pathway as one of the most affected oncogenic signaling pathways, and the Extracellular matrix organization as the most significant biological process affected
irritans is involved in the defense against oxidative stress induced by zinc ions
Usage Cited in: Signal Transduct Target Ther
Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored
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