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The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]
Interconnectivities and differences between menstrual cycle phases were visualized using custom MATLAB (Mathwork Inc.) scripts and edited using yEd (yWorks GmbH) 17,18,97,98,99
The effect is gradual and works best over 3 to 6 months
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