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The effect of the GSH depletion on the cell proliferation, defined by mean percentages of cells in phases S+M/G2SD, is presented at the panel B, and the effect of the depletion on the cell death, i.e
Since co-treatment of UK-5099 and JMF4073 depleted dTTP pool and suppressed the growth of T315-Bcr-Abl-32D cells, we proposed that reducing GSH biosynthesis induces not only oxidative stress but also replication stress in tumor cells, which demands the synthesis of dTTP and dCTP for survival
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