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Targeting the synapse in Alzheimers disease
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185 In EGFR-mutant lung cancer, resistance to osimertinib is tightly linked to epigenetic regulation by the ATPase subunit SMARCA4 of the mSWI/SNF complex
As superoxide is subject to efficient dismutation by cellular superoxide dismutases, it is possible that NFT might directly interact with Keap1 to induce the observed release of Nrf2 and its escape from proteasomal degradation
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