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A network meta-analysis of 22 RCTs covering 2,258 participants found GLP-1 receptor agonists reduced lean mass by a mean of 0.86 kg, with lean mass comprising roughly 25% of total weight lost across agents
Factors influencing skin adaptation include age, genetics, duration of obesity, hydration status, nutritional adequacy (particularly protein intake), and concurrent exercise
The incidence of this behaviour is increasing ..This appears to be due to a cost saving exercise and largely happens without any prior consultation with individual patients to discuss their needs
Timing considerations: Different peptides have different half-lives and optimal administration timing
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