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To provide novel concepts and strategies for overcoming AML treatment resistance and improving patient outcomes, the present review examines the RCD modes of action, their key functions, and potential synergistic effects in maintaining LSCs, chemoresistance and bone marrow microenvironment remodeling

2025 NCT06354660 TRANSCEND-T2D-1 Phase 3 clinical trial

In our analysis, metformin demonstrated indirect modulation of herpesvirus-associated pathways, supporting the possibility that its protective effects in DM2AD comorbidity may partially involve interference with viral mechanisms

Vollmer DL, West VA, Lephart ED