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If Grade 2 nausea persists despite pausing escalation, or if vomiting occurs, the dose should be reduced to the last well tolerated dose rather than discontinued
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In clinical trials of semaglutide for type 2 diabetes mellitus, patients exposed to semaglutide subcutaneous injection reported increases in amylase (hyperamylasemia) and lipase, and had a mean increase from baseline in amylase of 13% and lipase of 22%
She also finds it helpful for women who are trying to conceive, are pregnant or postpartum, or have PCOS because it supports mitochondrial function, reduces oxidative stress, and helps regulate metabolismall of which are especially helpful for women facing fertility challenges or mental burnout
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