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Phase II and III randomized, double-blind, controlled studies comparing l-glutamine 0.6 g/kg/day to placebo in adults and children with SCD and two episodes of pain in the previous year provide evidence that l-glutamine is helpful and linked to a decrease in painful episodes and hospitalization

Metabolically, GLP-1 acts through G protein-coupled receptors to improve insulin sensitivity in muscle and adipose tissues while enhancing -cell function by promoting proliferation and inhibiting apoptosis (see Figure 3)

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