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While body weight and metabolic phenotypes remain the primary endpoints, the outcome spectrum is progressively extending toward lipotoxic load [e.g., hepatic fat and visceral adipose tissue (VAT)], inflammatory/cardiometabolic risk markers, and reproductive outcomes with higher clinical decision-making value, such as menstruation, ovulation, and pregnancy

Do not take extra medicine to make up for the missed dose

Bariatric surgery is also highly effective, and a one-time cost

Mechanistically, SELENOP promotes IR by inhibiting the phosphorylation of Acetyl-CoA carboxylase (ACC), a critical enzyme in lipid metabolism